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- **********************************
- * Glycoprotease family signature *
- **********************************
-
- Glycoprotease (GCP) (EC 3.4.24.57) [1] or (o-syaloglycoprotein endopeptidase)
- is a metalloprotease secreted by Pasteurella haemolytica which specifically
- cleaves O-sialoglycoproteins such as glycophorin A. The sequence of GCP is
- highly similar to the following uncharacterized proteins:
-
- - Escherichia coli hypothetical protein ygjD (ORF-X).
- - Haloarcula marismortui hypothetical protein in HSH 3'region.
- - Yeast hypothetical protein YKR038c.
-
- One of the conserved regions contains two conserved histidines. It is possible
- that this region be involved in the coordination of a metal ion such as zinc.
-
- -Consensus pattern: R-[SAT]-x(4)-[FYW]-[DN]-x-P-x-[LIVM]-x-V-x-H-x(2)-[AG]-H-
- [LIVM]
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
- -Last update: June 1994 / First entry.
-
- [ 1] Abdullah K.M., Lo R.Y., Mellors A.
- J. Bacteriol. 173:5597-5603(1991).
-